产品货号：
Z18019
中文名称：
HLA-DQA1抗体
英文名称：
Anti-HLA-DQA1 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HLA-DQA1 Antibody (C-term) |
| 指标别名 | CELIAC1;DC 1 alpha chain;DC alpha;DQ A1;GSE;HLA DCA;HLA DQA;HLA DQA1;HLA-DQA1;MHC class II DQA1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,FCM,IF |
| 基因名称 | HLA-DQA1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This HLA-DQA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 188-222 amino acids from the C-terminal region of human HLA-DQA1. |
| 计算分子量 | 28kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells.The peptide binding cleft accommodates peptides of 10-30 residues.The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route,where they are processed by lysosomal proteases and other hydrolases.Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules,and for this reason this antigen presentation pathway is usually referred to as exogenous.As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments,exogenous antigens must compete with those derived from endogenous components.Autophagy is also a source of endogenous peptides,autophagosomes constitutively fuse with MHC class II loading compartments.In addition to APCs,other cells of the gastrointestinal tract,such as epithelial cells,express MHC class II molecules and CD74 and act as APCs,which is an unusual trait of the GI tract.To produce a MHC class II molecule that presents an antigen,three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer.Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs,CD74 undergoes a sequential degradation by various proteases,including CTSS and CTSL,leaving a small fragment termed CLIP (class-II-associated invariant chain peptide).The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released.HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound.The MHC II molecule bound to a peptide is then transported to the cell membrane surface.In B-cells,the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.Primary dendritic cells (DCs) also to express HLA-DO.Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules,increased acidification produces increased proteolysis and efficient peptide loading. |
| Uniprot ID | P01909 |
相关搜索：HLA-DQA1抗体，HLA-DQA1(C-term)多抗，Anti-HLA-DQA1 Antibody (C-term)